Healthcare
Professionals Schools
& Nurseries Dental Professionals
The discovery of stem cells in children's primary teeth will have a profound impact on 21st century medicine, and it will put dentistry at the forefront of cutting-edge medical technology. In fact, Dr. Pamela Gehron Robey, Ph.D., Chief, Craniofacial and Skeletal Disease Branch, National Institute of Dental and Craniofacial Research of the National Institute of Health, Department of Health and Human Services, foresaw the value of tooth cell banking and encouraged the practice. You can read a summary of her 2005 address to the American Dental Association at http://www.ada.org/public/media/releases/0506_release04.asp.
Since this discovery is so recent, and the cells from children's primary teeth are so readily obtainable, it is certain that a vast amount of research will be conducted using these cells—research that will lead to new cures for a host of diseases and disorders, including neuronal degenerative disorders such as Alzheimer's and Parkinson's diseases, ALS (amytrophic lateral sclerosis, or Lou Gehrig's disease); chronic heart conditions such as congestive heart failure and chronic ischemic heart disease. These cells can also be used to treat periodontal disease and to grow replacement teeth and bone.
One of the most important potential applications using this material is for treatment of paralysis due to spinal cord injury--treatment which has already been done using mesenchymal stem cells from other sources. Stem cell therapy does not just treat symptoms; stem cell therapy cures diseases.
The future of stem cell therapies is promising. The application of stem cell therapy is currently being pursued by many of the brightest minds at the best instiutions around the world. Current funding for stem cell research is in excess of $6 billion worldwide, and there are thousands of ongoing clinical trials that involve stem cells.
If you would like to discuss how you can make this procedure available to your patients, please call us at 888-315-3843 x2, or send an email to contact@bioeden.com.
The links below are a sampling of ongoing research using the same types of cells found in children's primary teeth:
Relevant Scientific Publications
Publications are in reverse
chronological order
2008
Publications
Isolation
of Distinct Progenitor Stem Cell Populations from Dental Pulp.
Waddington RJ, Youde SJ, Lee CP, Sloan AJ.
Cells Tissues Organs. 2008 Aug 14. PMID: 18701814
Putative
Dental Pulp Derived Stem/Stromal Cells Promote Proliferation and
Differentiation of Endogenous Neural Cells in the Hippocampus of Mice.
Huang AH, Snyder BR, Cheng PH, Chan AW.
Stem Cells. 2008 Aug 7
http://www.ncbi.nlm.nih.gov/sites/entrez
Dental
pulp tissue engineering with stem cells from exfoliated deciduous teeth.
Cordeiro MM, Dong Z,
Kaneko T, Zhang Z, Miyazawa M, Shi S, Smith AJ, Nör JE.
J
Endod. 2008 Aug;34(8):962-9. PMID: 18634928
Adult
human dental pulp stem cells differentiate toward functionally active neurons
under appropriate environmental cues.
Arthur A, Rychkov G, Shi S, Koblar SA, Gronthos S.
Stem Cells. 2008 Jul;26(7):1787-95.
Self-Assembling
Peptide Amphiphile Nanofibers as a Scaffold for Dental Stem Cells.
Galler KM, Cavender A,
Yuwono V, Dong H, Shi S, Schmalz G, Hartgerink JD, D'Souza RN.
Tissue Eng Part A.
2008 Jul 17. PMID: 18636949
Stem
cells and periodontal regeneration.
Lin NH, Gronthos S, Bartold PM.
Aust Dent J. 2008 Jun;53(2):108-21.
Collection,
cryopreservation, and characterization of human dental pulp-derived mesenchymal
stem cells for banking and clinical use.
Perry
BC, Zhou D, Wu X, Yang FC, Byers MA, Chu TM, Hockema JJ, Woods EJ, Goebel WS.
Tissue
Eng Part C Methods. 2008 Jun;14(2):149-56. PMID: 18489245
Human dental pulp stem cells improve
left ventricular function, induce angiogenesis, and reduce infarct size in rats
with acute myocardial infarction.
Gandia C, Armiñan A, García-Verdugo JM,
Lledó E, Ruiz A, Miñana MD, Sanchez-Torrijos J, Payá R,
Mirabet V, Carbonell-Uberos F, Llop M, Montero JA, Sepúlveda P.
Stem Cells. 2008 Mar;26(3):638-45. Epub 2007
Dec 13.
Human
dental pulp stem cells differentiate into neural crest- derived melanocytes and
have label-retaining and sphere-forming abilities.
Stevens A, Zuliani T, Olejnik C, Leroy H, Obriot H,
Kerr-Conte J, Formstecher P, Bailliez Y, Polakowska RR.
Stem Cells Dev. 2008 Mar 25. PMID: 18393638
In
vivo evaluation of human dental pulp stem cells differentiated towards multiple
lineages.
Zhang W, Walboomers XF, Van Kuppevelt TH, Daamen WF, Van
Damme PA, Bian Z, Jansen JA.
J Tissue Eng Regen Med. 2008 Mar-Apr;2(2-3):117-25. PMID: 18338838
Reconstruction
of large cranial defects in nonimmunosuppressed experimental design with human
dental pulp stem cells.
de Mendonça Costa A, Bueno DF, Martins MT, Kerkis I,
Kerkis A, Fanganiello RD, Cerruti H, Alonso N, Passos-Bueno MR.
J Craniofac Surg. 2008 Jan;19(1):204-10. PMID: 18216690
Dental
pulp stem cells: a promising tool for bone regeneration.
d'Aquino R, Papaccio G, Laino G, Graziano A.
Stem Cell Rev. 2008 Spring;4(1):21-6. PMID: 18300003
2007
Publications
Mesenchymal
progenitor cells in adult human dental pulp and their ability to form bone when
transplanted into immunocompromised mice.
Otaki S, Ueshima S, Shiraishi K, Sugiyama K, Hamada S,
Yorimoto M, Matsuo O.
Cell Biol Int. 2007 Oct;31(10):1191-7.
Epub 2007 Apr 14.
PMID: 17524678 [PubMed - in process]
Human
postnatal dental pulp cells co-differentiate into osteoblasts and
endotheliocytes: a pivotal synergy leading to adult bone tissue formation.
d'Aquino R, Graziano A, Sampaolesi M, Laino G, Pirozzi G, De
Rosa A, Papaccio G.
Cell Death Differ. 2007 Jun;14(6):1162-71.
Epub 2007 Mar 9.
PMID: 17347663
Concave
pit-containing scaffold surfaces improve stem cell-derived osteoblast performance
and lead to significant bone tissue formation.
Graziano A, d'Aquino R, Cusella-De Angelis MG, Laino G,
Piattelli A, Pacifici M, De Rosa A, Papaccio G.
PLoS ONE. 2007 Jun 6;2:e496.
PMID: 17551577
Transplantation
of mesenchymal stem cells is an optimal approach for plastic surgery.
Fang D, Seo BM, Liu Y, Sonoyama W, Yamaza T, Zhang C, Wang
S, Shi S.
Stem Cells. 2007 Apr;25(4):1021-8. Epub 2006
Dec 14. PMID: 17170063
In
vitro stem cell cultures from human dental pulp and periodontal ligament: new
prospects in dentistry.
Ballini A, De Frenza G, Cantore S, Papa F, Grano M,
Mastrangelo F, Tete S, Grassi FR.
Int J Immunopathol Pharmacol. 2007 Jan-Mar;20(1):9-16.
Review.
PMID: 17346423
Multilineage
potential of STRO-1+ rat dental pulp cells in vitro.
Yang X, Zhang W, van den Dolder J, Walboomers XF, Bian Z,
Fan M, Jansen JA.
J Tissue Eng Regen Med. 2007 Mar-Apr;1(2):128-35. PMID: 18038401
Human
dental pulp stem cells--isolation and long term cultivation.
Suchánek J, Soukup T, Ivancaková R, Karbanová
J, Hubková V, Pytlík R, Kucerová L.
Acta Medica (Hradec Kralove). 2007;50(3):195-201. PMID: 18254273
2006
Publications
Mesenchymal
stem cell-mediated functional tooth regeneration in Swine.
Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, Zhang C, Liu H,
Gronthos S, Wang CY, Shi S, Wang S.
PLoS ONE. 2006 Dec 20;1:e79.
PMID: 17183711
Transplantation
of Mesenchymal Stem Cells is an Optimal Approach for Plastic Surgery.
Fang D, Seo BM, Liu Y, Sonoyama W, Yamaza T, Zhang C, Wang
S, Shi S.
Stem Cells. 2006 Dec 14; PMID: 17170063
The
performance of human dental pulp stem cells on different three-dimensional
scaffold materials.
Zhang W, Frank Walboomers X, van Kuppevelt TH, Daamen WF,
Bian Z, Jansen JA.
Biomaterials. 2006 Nov;27(33):5658-68. Epub 2006
Aug 17.
PMID: 16916542
Differentiation
of dental pulp stem cells into regular-shaped dentin-pulp complex induced by
tooth germ cell conditioned medium.
Yu J, Deng Z, Shi J, Zhai H, Nie X, Zhuang H, Li Y, Jin Y.
Tissue Eng. 2006 Nov;12(11):3097-105.
PMID: 17518625
Craniofacial
tissue engineering by stem cells.
Mao JJ, Giannobile WV, Helms JA, Hollister SJ, Krebsbach PH,
Longaker MT, Shi S.
J Dent Res. 2006 Nov;85(11):966-79.
Review.
PMID: 17062735
Multilineage
differentiation potential of stem cells derived from human dental pulp after
cryopreservation.
Zhang W, Walboomers XF, Shi S, Fan M, Jansen JA.
Tissue Eng. 2006 Oct;12(10):2813-23.
PMID: 17518650
Long-term
cryopreservation of dental pulp stem cells (SBP-DPSCs) and their differentiated
osteoblasts: a cell source for tissue repair.
Papaccio G, Graziano A, d'Aquino R, Graziano MF, Pirozzi G,
Menditti D, De Rosa A, Carinci F, Laino G.
J Cell Physiol. 2006 Aug;208(2):319-25.
PMID: 16622855
Cluster
analysis and gene expression profiles: a cDNA microarray system-based
comparison between human dental pulp stem cells (hDPSCs) and human mesenchymal
stem cells (hMSCs) for tissue engineering cell therapy.
Yamada Y, Fujimoto A, Ito A, Yoshimi R, Ueda M.
Biomaterials. 2006 Jul;27(20):3766-81. Epub 2006
Mar 24.
PMID: 16563496
In
vitro bone production using stem cells derived from human dental pulp.
Laino G, Carinci F, Graziano A, d'Aquino R, Lanza V, De Rosa
A, Gombos F, Caruso F, Guida L, Rullo R, Menditti D, Papaccio G.
J Craniofac Surg. 2006 May;17(3):511-5.
PMID: 16770190
An
approachable human adult stem cell source for hard-tissue engineering.
J Cell Physiol. 2006 Mar;206(3):693-701.
Laino G, Graziano A, d'Aquino R, Pirozzi G, Lanza V,
Valiante S, De Rosa A, Naro F, Vivarelli E, Papaccio G.
Dental
pulp stem cells.
Liu H, Gronthos S, Shi S.
Methods Enzymol. 2006;419:99-113.
PMID: 17141053
2005
Publications
A
new population of human adult dental pulp stem
cells: a useful source of living autologous fibrous bone tissue (LAB).
Laino G, d'Aquino R, Graziano A, Lanza V, Carinci F, Naro F,
Pirozzi G, Papaccio G.
J Bone Miner Res. 2005 Aug;20(8):1394-402. Epub 2005 Mar 28.
PMID: 16007337 [PubMed - in process]
The
efficacy of mesenchymal stem cells to regenerate and repair dental structures.
Shi S, Bartold PM, Miura M, Seo BM, Robey PG, Gronthos S.
Orthod Craniofac Res. 2005
Aug;8(3):191-9.
Making
a tooth: growth factors, transcription factors, and stem cells.
Zhang YD, Chen Z, Song YQ, Liu C, Chen YP.
Cell Res. 2005 May;15(5):301-16.
Identification
and isolation of human dental pulp stem cells.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2005 May;40(3):244-7.
Chinese.
Differentiation
ability of rat postnatal dental pulp cells in vitro.
Zhang W, Walboomers XF, Wolke JG, Bian Z, Fan MW, Jansen JA.
Tissue Eng. 2005 Mar-Apr;11(3-4):357-68.
Isolation and
identification of huamn dental pulp stem cells.
Hua Xi Kou Qiang Yi Xue Za Zhi.
2005 Feb;23(1):75-8. Chinese.
2004
Publications
Reconstruction
of human mandible by tissue engineering.
Gronthos S.
Lancet. 2004 Aug 28-Sep 3;364(9436):735-6. No abstract
available.
Investigation
of multipotent postnatal stem cells from human periodontal ligament.
Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim
J, Young M, Robey PG, Wang CY, Shi S.
Lancet. 2004 Jul 10-16;364(9429):149-55.
Dentonin,
a fragment of MEPE, enhanced dental pulp stem cell proliferation.
Liu H, Li W, Gao C, Kumagai Y, Blacher RW, DenBesten PK.
J Dent Res. 2004 Jun;83(6):496-9.
Dental pulp cells provide neurotrophic support for
dopaminergic neurons and differentiate into neurons in vitro; implications for
tissue engineering and repair in the nervous system.
Nosrat IV, Smith CA,
Mullally P, Olson L, Nosrat CA.
Eur J Neurosci. 2004 May;19(9):2388-98.
PMID: 15128393
2003
Publications
Comparison of stem-cell-mediated
osteogenesis and dentinogenesis.
J Dent Res. 2003 Dec;82(12):976-81.
Batouli S, Miura M,
Brahim J, Tsutsui TW, Fisher LW, Gronthos S, Robey PG, Shi S.
PMID: 14630898
Perivascular niche of postnatal
mesenchymal stem cells in human bone marrow and dental pulp.
Shi S, Gronthos S.
J Bone Miner Res. 2003
Apr;18(4):696-704.
SHED:
stem cells from human exfoliated deciduous teeth.
Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi
S.
Proc Natl Acad Sci U S A. 2003 May
13;100(10):5807-12. Epub 2003 Apr 25.
PMID: 12716973
Responses of rat trigeminal
neurones to dental pulp cells or fibroblasts overexpressing neurotrophic
factors in vitro.
Lillesaar C, Arenas E,
Hildebrand C, Fried K.
Neuroscience. 2003;119(2):443-51.
PMID: 12770558
Analysis
of tooth formation by reaggregated dental mesenchyme from mouse embryo.
Yamamoto H, Kim EJ, Cho SW, Jung HS.
J Electron Microsc (
Publications
before 2003
Tissue
engineering of complex tooth structures on biodegradable polymer scaffolds.
Young CS, Terada S, Vacanti JP, Honda
M, Bartlett JD, Yelick PC.
J Dent Res. 2002 Oct;81(10):695-700.
Stem
cell properties of human dental pulp stem cells.
Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A,
DenBesten P, Robey PG, Shi S.
J Dent Res. 2002 Aug;81(8):531-5.
Comparison of human
dental pulp and bone marrow stromal stem cells by cDNA microarray analysis.
Shi S, Robey PG, Gronthos S.
Bone. 2001 Dec;29(6):532-9.
Dental pulp cells produce neurotrophic factors, interact
with trigeminal neurons in vitro, and rescue motoneurons after spinal cord
injury.
Nosrat IV, Widenfalk J, Olson L, Nosrat CA.
Dev Biol. 2001 Oct 1;238(1):120-32.
Postnatal human dental pulp stem
cells (DPSCs) in vitro and in vivo.
Gronthos S, Mankani M, Brahim J, Robey PG, Shi S.
Proc Natl Acad Sci U S
A. 2000 Dec 5;97(25):13625-30.
Selected publication list assembled by BioEDEN, Inc, 2008.
There are currently 484 peer reviewed relevant publications at www.pubmed.gov